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Hornet stings are frequently encountered in practice in Nepal. Majority of patients sustain minor illness. However, complications like anaphylactic shock and the rare acute kidney injury, multiple organ dysfunction and acute myocardial infarction have been reported. Ischemic stroke following hornet stings has been reported infrequently in scientific publications. We report a case of fatal right Middle Cerebral artery territory ischemic stroke and acute kidney injury in a 40-year farmer.