The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas Our experience on a series of 81 cases

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A. I. Cucu
Claudia Florida Costea
Mihaela Dana Turliuc
Cristina Gena Dascalu
Ioana Jitaru
R. Dinu
Gabriela Dumitrescu
Anca Sava
B. Dobrovat
Camelia Bogdanici
T. Andrei
I. Stirban
I. Poeata

Abstract

Objective: The objective of our study was to evaluate a possible relation between the volume of atypical meningiomas (AMs) and the risk of tumour recurrence, as well as progression-free survival (PFS).


Material and methods: We evaluated 81 patients diagnosed with AMs (WHO grade II meningioma) who have undergone surgery at the "Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi between January 1, 2010, and December 31, 2019. The recorded data were demographic and imagistic (MRI, contrast-enhanced T1WI). We calculated the tumour volume prior to the surgery and evaluated the tumour recurrence using MRI at 12, 24, 36, 48 and 60 months after the surgery.


Results: 50.6% of patients had meningioma volume < 26.4 cm3. Women had larger tumour volumes than men (52.6%). Patients of age ≤ 60 years old, had tumour volumes ˃ 26.4 cm3 in 58.5% of cases and meningiomas with volumes ˃ 26.4 cm3 recurred earlier (p=0.010). Also, patients who had tumour volumes ˃ 26.4 cm3, had a shorter PFS (40.976 months), compared to patients with tumour volumes < 26.4 cm3, who had better PFS (53.4 months).


Conclusions: the tumour volume of AMs ˃ 26.4 cm3 represents a negative prognostic factor for both early tumour recurrence and reduced PFS.

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How to Cite
Cucu, A., Costea, C., Turliuc, M., Dascalu, C., Jitaru, I., Dinu, R., Dumitrescu, G., Sava, A., Dobrovat, B., Bogdanici, C., Andrei, T., Stirban, I., & Poeata, I. (2020). The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas. Romanian Neurosurgery, 34(1), 163-168. Retrieved from https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/1364
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Author Biographies

A. I. Cucu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

Claudia Florida Costea

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

Mihaela Dana Turliuc

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

Cristina Gena Dascalu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

Ioana Jitaru

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

R. Dinu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

Gabriela Dumitrescu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

Anca Sava

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

B. Dobrovat

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

Camelia Bogdanici

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania

T. Andrei

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

I. Stirban

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

I. Poeata

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iasi, Romania

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania