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A rare case of glioblastoma multiforme (GBM) of septum pellucidum is being reported. There were symptoms of altered behaviour, memory and changes in sensorium. The MRI was suggestive of a tumour arising from the septum pellucidum. Glioblastomas arising from septum pellucidum are rare. While even a partial endoscopic excision of the more common pathology viz. colloid cyst is acceptable, only, a safe maximal excision of a highly malignant pathology like glioblastoma is an acceptable goal in order to give any benefit of surgical exploration to the patient.