Microbiota Gut-Brain Axis and Neurodegenerative Disease A systematic review on Alzheimer’s disease, Amyotrophic lateral sclerosis and Parkinson Disease

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Poluyi Edward Oluwatobi
Imaguezegie Grace Ese
Poluyi Abigail Oluwatumininu
Morgan Eghosa

Abstract

This review highlights the microbiota gut-brain axis and neurodegenerative diseases excluding studies on animal models. Gut microbiota is capable of modulating some brain activities via the microbiota gut-brain axis. A bidirectional communication exists between the gastrointestinal (GI) tract and the central nervous system (CNS) in the microbiota gut-brain axis. Gut dysbiosis has been linked to neurodegenerative diseases as a result of the imbalance in the composition of its microbiota, which has a damaging effect on the host’s health. The association between the role and mechanism of CNS disease and gut microbial is yet to be fully explored. Although some studies have shown a positive relationship between a rich diverse microbial community and the brain of the host, and a negative relationship between microbial dysbiosis, intestinal infection and human brain health, our knowledge, however, is limited due to the inability to identify the major players in this heterogeneous microbial community.

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How to Cite
Oluwatobi, P., Ese, I., Oluwatumininu, P., & Eghosa, M. (2020). Microbiota Gut-Brain Axis and Neurodegenerative Disease. Romanian Neurosurgery, 34(1), 110-116. Retrieved from https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/1350
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Articles
Author Biographies

Poluyi Edward Oluwatobi

Department of Life Science, Clinical Neuroscience, University of Roehampton, London, United Kingdom

Imaguezegie Grace Ese

Lagos University Teaching Hospital, Idi-araba, Surulere, Lagos, Nigeria

Poluyi Abigail Oluwatumininu

College of Medicine, University of Lagos, Nigeria

Morgan Eghosa

Ambrose Alli University, Ekpoma, Edo, Nigeria