Preliminary study of thrombogenicity induced by the nanoparticle surface coating of intracranial stents

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A. Chiriac
Georgiana Ion
G. Stan
T. Popescu
Mihaela Sofronie
I. Poeata

Abstract

Endovascular treatment of intracranial aneurysms with intracranial stents was proven to be clinically safe and effective, but is still associated with a risk of thromboembolic complications. Stent thrombosis could be a sever complication associated with specific stent surface coatings and designs. Standardized in vitro tests for investigation of thrombogenicity induced by different nanomaterials were used as the basic method in carrying out the present study. Therefore, the aim of this study was to evaluate the thrombogenicity of three different nanomaterials (ZnO, TiO2 si Fe3O4) possible used as surface coating for intracranial stents. This study is based on a procedure for in vitro analyses of plasma coagulation time. To measure the plasma coagulation time, platelet-poor plasma from human whole blood was in vitro exposed to nanoparticles and analysed in prothrombin (PT) and activated partial thromboplastin (APTT).

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How to Cite
Chiriac, A., Ion, G., Stan, G., Popescu, T., Sofronie, M., & Poeata, I. (2019). Preliminary study of thrombogenicity induced by the nanoparticle surface coating of intracranial stents. Romanian Neurosurgery, 33(4), 404-410. https://doi.org/10.33962/roneuro-2019-085
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Articles
Author Biographies

A. Chiriac

“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Georgiana Ion

“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

G. Stan

National Institute of Materials Physics, Bucharest-Magurele, Romania

T. Popescu

National Institute of Materials Physics, Bucharest-Magurele, Romania

Mihaela Sofronie

National Institute of Materials Physics, Bucharest-Magurele, Romania

I. Poeata

“Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania