Spontaneous cerebrospinal fluid rhinorrhea in a patient with Pallister–Hall syndrome

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Milicevic Mihajlo
Aleksic Vuk
Ilic Rosanda
Scepanovic Vuk
Stanimirovic Aleksandar
Paunovic Aleksandra
Milic Marina
Nedeljkovic Zarko
Matteo Sacco
Grujicic Danica

Abstract

Pallister-Hall syndrome (PHS) is extremely rare autosomal dominant disorder with typical clinical features such as presence of polydactyly, hypothalamic hamartoma, bifid epiglottis, anal, renal, genitourinary and pulmonary abnormalities, mainly located in the midline of the body. Spontaneous cerebrospinal fluid (CSF) rhinorrhea is also a rare condition, and it is used to describe nasal discharge of CSF unrelated to previous trauma, localized tumour, surgery, or previous radiation therapy. The exact cause is not yet fully understood.


We report a case of adult female patient previously diagnosed with PHS and late onset of spontaneous nasal liquorrhea, due to defect in the anterior skull base. Although it can be incidental finding, we believe that described defect in the body midline can be another presentation of congenital craniofacial abnormality which are common in PHS.

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How to Cite
Mihajlo, M., Vuk, A., Rosanda, I., Vuk, S., Aleksandar, S., Aleksandra, P., Marina, M., Zarko, N., Sacco, M., & Danica, G. (2019). Spontaneous cerebrospinal fluid rhinorrhea in a patient with Pallister–Hall syndrome. Romanian Neurosurgery, 33(3), 305-309. https://doi.org/10.33962/roneuro-2019-051
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Author Biographies

Milicevic Mihajlo

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Faculty of Medicine, University of Belgrade, Belgrade, SERBIA

Aleksic Vuk

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Ilic Rosanda

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Faculty of Medicine, University of Belgrade, Belgrade, SERBIA

Scepanovic Vuk

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Stanimirovic Aleksandar

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Paunovic Aleksandra

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Milic Marina

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Nedeljkovic Zarko

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Matteo Sacco

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Grujicic Danica

Neurosurgery Clinic, Clinical Center of Serbia, Belgrade, SERBIA

Faculty of Medicine, University of Belgrade, Belgrade, SERBIA