“The Silk Road” via subarachnoid cisterns Cerebrospinal fluid dissemination of meningiomas

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A. I. Cucu
Mihaela Dana Turliuc
Claudia Florida Costea
B. Costăchescu
Cristina Mihaela Ghiciuc
B. Dobrovăț
Camelia Margareta Bogdănici
Daniela Maria Tănase
Gabriela Florența Dumitrescu
Anca Sava
I. Poeată

Abstract

Meningiomas are generally slow-growing extra-axial benign tumours and in rare cases they can metastasize both neural and extra-neural. Intracranial meningiomas with leptomeningeal dissemination are extremely rare and the exact pathogenesis still remains unknown. The aim of this review is to analyse the pathways of intracranial and spinal metastatic spread of intracranial meningiomas and to discuss their particular clinical and pathological features. We highlight the fact that there is a possibility of leptomeningeal dissemination, even if cerebrospinal fluid cytology is negative, in patients with a medical history of a resected meningioma. We identified three possible ways of dissemination: haematogenous, through the CSF, or during surgery. From a histopathological point of view, the more malignant the meningioma, the more likely its leptomeningeal dissemination.

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How to Cite
Cucu, A., Turliuc, M., Costea, C., Costăchescu, B., Ghiciuc, C., Dobrovăț, B., Bogdănici, C., Tănase, D., Dumitrescu, G., Sava, A., & Poeată, I. (2019). “The Silk Road” via subarachnoid cisterns. Romanian Neurosurgery, 33(3), 260-267. https://doi.org/10.33962/roneuro-2019-043
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Author Biographies

A. I. Cucu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

Mihaela Dana Turliuc

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

Claudia Florida Costea

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

B. Costăchescu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

Cristina Mihaela Ghiciuc

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

B. Dobrovăț

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

Camelia Margareta Bogdănici

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

Daniela Maria Tănase

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

Gabriela Florența Dumitrescu

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

Anca Sava

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA

I. Poeată

"Prof. Dr. N. Oblu" Emergency Clinical Hospital Iași, ROMANIA

"Grigore T. Popa" University of Medicine and Pharmacy Iași, ROMANIA