Diagnostic value of preoperative systemic inflammatory markers in patients with intracranial meningiomas

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Rahsan Kemerdere
Mehmet Yigit Akgun
Sureyya Toklu
Orkhan Alizada
Oguz Baran
Taner Tanriverdi

Abstract

Introduction: The role of inflammation in cancer has been defined, and now, inflammation is accepted as one of the hallmarks of cancer development. The aim of this study was to evaluate the difference regarding preoperative neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) in patients with meningioma between patients and healthy controls and between grade-I and grade-II meningiomas. Methods: Retrospective analysis of preoperative neutrophil, lymphocyte, monocyte, and platelet counts and NLR, and PLR were evaluated in 61 patients underwent meningioma surgery. Results: Neutrophil count was significantly increased while lymphocyte count significantly decreased patients compared to controls. Similar findings were obtained in grade-II meningiomas compared with grade-I meningiomas. NLR were significantly higher in both grade-I and grade-II meningiomas than controls. Conclusion: We for the first time provided that higher NLR may be associated with grading of meningioma and be a predictive factor for progression of meningiomas. The use of medication against neutrophil-related inflammation may be helpful for patients with higher grade of meningioma decreasing peritumoral edema before and after surgery.

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How to Cite
Kemerdere, R., Akgun, M. Y., Toklu, S., Alizada, O., Baran, O., & Tanriverdi, T. (2018). Diagnostic value of preoperative systemic inflammatory markers in patients with intracranial meningiomas. Romanian Neurosurgery, 32(4), 613–621. Retrieved from https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/1137
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Author Biographies

Rahsan Kemerdere

Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TURKEY

Mehmet Yigit Akgun

Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TURKEY

Sureyya Toklu

Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TURKEY

Orkhan Alizada

Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TURKEY

Oguz Baran

Neurosurgery Clinic, Istanbul Research and Training Hospital, Istanbul, TURKEY

Taner Tanriverdi

Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, TURKEY